by Albert-Laszlo Barabasi, Edwin K. Silverman, Joseph Loscalzo ✦ Review by David Lorimer, August 2017
Subtitled 'complex systems in human disease and therapeutics', this volume builds on big data, genomics and quantitative approaches to network-based analysis. The book goes beyond the model of identifying singular molecular defects as the cause of disease to a consideration of the inherent complexity of human diseases, a lack of understanding of which has led to inappropriate treatments with adverse side-effects. The new network medicine embraces this complexity at many levels but stops short of considering the role of the mind in influencing molecular processes. Chapters include coverage of epigenetics, metabolomics, microbiomics, systems pharmacology and systems approaches to clinical trials. The number of elements and levels of complexity are mind-boggling and this book provides an excellent technical introduction to the field for specialists rather than the general reader.
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